Entresto Description

sacubitril + valsartan




Zuellig Pharma
The information highlighted (if any) are the most recent updates for this brand.
Full Prescribing Info
Entresto film coated tablets contains 50 mg (sacubitril/valsartan).*
Entresto film coated tablets contains 100 mg (sacubitril/valsartan).*
Entresto film coated tablets contains 200 mg (sacubitril/valsartan).*
* Certain dosage strengths may not be available in all countries.
Entresto contains a salt complex of the anionic forms of sacubitril and valsartan, sodium cations, and water molecules in the molar ratio of 1:1:3:2.5 respectively. The empirical formula of the complex (hemipentahydrate) is C48H55N6O8Na3 2.5 H2O. Its molecular mass is 957.99.
Following oral administration, the complex dissociates into sacubitril (which is further metabolized to sacubitrilat) and valsartan.
Excipients/Inactive Ingredients: Microcrystalline cellulose, low-substituted hydroxypropylcellulose, crospovidone, magnesium stearate (vegetable origin), talc and colloidal silicon dioxide.
Excipients of film coating: Hypromellose, titanium dioxide (E 171), Macrogol 4000, talc, iron oxide red (E 172).
For 50 and 200 mg: Iron oxide black (E 172). For 100 mg: Iron oxide yellow (E 172).
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