Route of administration: IV, SC.
Eposis is administered at an initial dose of 50 units/kg for 1-2 minutes three times a week. It can be given by either an intravenous or subcutaneous route. The dose increase is dependent upon the initial response. The dose increase is dependent upon the initial response. The dose can be increased, if necessary, by 25 units/kg in 4-week period. If hemoglobin is increased more than 2 g/dl at a dose of 50 units/kg, the frequency should be reduced to two times a week. To correct the anemia, the target concentration of hemoglobin is 10 g/ dl (30% as hematocrit). When the anemia is corrected, Eposis is given as a maintenance dose of 25 - 50 units/kg two or three times a week. The target range of hemoglobin is 10-12 g/dl. The patients with the treatment hemoglobin < 6 g/ dl need higher maintenance dose than the patients with pretreatment hemoglobin ≥ 8 g/ dl. And the dose may be adjusted according to the age of patients. The unit dose of Eposis should not be exceed of 200 units/kg, and the frequency should not be more than three times a week. Prior to initiation of therapy or during the therapy, the patient's iron stores should be evaluated, if necessary, iron should be supplied. If the patients are in aluminum intoxication or infected, delayed or diminished responses may be occurred. In patients with CRF not on dialysis, the maintenance dose must also be individualized according to the severity of anemia or age, however, the dose of 70 - 150 units/kg per week have been shown to maintain 36 - 38% of hematocrit for more than six months.