In studies in female rats, there were decreases in body weight gain, delayed ossification, and increases of mortality when given in doses 20 times the 1week human dose.
Epoetin alfa has not shown any adverse effect at doses as high as 500 Unit/kg in pregnant rabbits (from day 6 to 18 of gestation).
Safety of the administration during pregnant is not established. So it is desirable not to administer in pregnant women or women of childbearing potential. But it should be given only if the benefits clearly outweigh any possible risk.
It is not known whether Eposis is excreted in human milk. Therefore, the administration should be avoided to nursing mother.
No adequate clinical experience in human pregnancy and lactation has been gained.