Eprex Drug Interactions

epoetin alfa




Full Prescribing Info
Drug Interactions
No evidence exists that indicates that treatment with Epoetin alfa alters the metabolism of other drugs. Drugs that decrease erythropoiesis may decrease the response to Epoetin alfa.
Since cyclosporin is bound by red blood cells there is potential for a drug interaction. If Epoetin alfa is given concomitantly with cyclosporin, blood levels of cyclosporin should be monitored and the dose of cyclosporin adjusted as the haematocrit rises.
No evidence exists that indicates an interaction between Epoetin alfa and G-CSF or GM-CSF with regard to haematological differentiation or proliferation of tumour cells from biopsy specimens in vitro.
The effect of Epoetin alfa may be potentiated by the simultaneous therapeutic administration of a haematinic agent, such as ferrous sulphate, when a deficiency state exists.
In patients with metastatic breast cancer, subcutaneous co-administration of 40,000 IU/mL Epoetin alfa with trastuzumab (6 mg/kg) had no effect on the pharmacokinetics of trastuzumab.
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