Upper resp tract infection, bronchitis, cystitis, skin infection; inj site bleeding, bruising, erythema, itching, pain, swelling. Allergic reactions; pruritus, rash; pyrexia. Non-melanoma skin cancers; worsening & new onset of congestive cardiac failure. Malignant melanoma, lymphoma, leukaemia; CNS demyelinating events suggestive of multiple sclerosis or localised demyelinating conditions eg, optic neuritis & transverse myelitis, peripheral demyelinating events, including Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, demyelinating polyneuropathy, multifocal motor neuropathy; Stevens-Johnson syndrome. Toxic epidermal necrolysis.