Initially 0.5 mg/kg loading dose infused over a min duration followed by maintenance infusion 0.05 mg/kg/min for the next 4 min. May be continued at 0.05 mg/kg/min or increased step-wise w/ each step maintained for ≥4 min. Intra- & post-op tachycardia &/or HTN
Immediate control (tachycardia &/or HTN intraop treatment): 80 mg bolus dose over 30 sec followed by 150 mcg/kg/min infusion, if necessary. Adjust the infusion rate as required up to 300 mcg/kg/min to maintain desired heart rate &/or BP. Gradual control (post-op tachycardia & HTN): Initially 500 mcg/kg/min loading dose infusion for 1 min followed by a 4-min maintenance infusion of 50 mcg/kg/min. If adequate therapeutic effect is not observed w/in 5 min, repeat same loading dose & followed by a maintenance infusion increased to 100 mcg/kg/min.