Ventilatory support is mandatory until adequate spontaneous respiration is restored. Consider use of reversal agent in cases where residual curarization may occur. Previous anaphylactic reactions to neuromuscular blocking agents. Hepatic &/or biliary tract & renal diseases. Prolonged circulation time eg, CV disease, old age & edematous state. Patients w/ neuromuscular disease or after poliomyelitis. Hypothermia, obesity, burns. Hypokalaemia, hypermagnesemia, hypocalcemia, hypoproteinemia, dehydration, acidosis, hypercapnia, cachexia. Correct severe electrolyte disturbances, altered blood pH or dehydration when possible. Monitor neuromuscular transmission during therapy. Myopathy may occur w/ long-term therapy. Delay administration if suxamethonium is used for intubation. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn (facilitating tracheal intubation conditions, during rapid sequence conditions; mechanical ventilation in the intensive care). Elderly (facilitating mechanical ventilation in the intensive care).