Allergic disorders; cardiac impairment (NSAIDs may impair renal function); coagulation defects; connective-tissue disorders; Crohn's disease (may be exacerbated); dehydration; history of cardiac failure; hypertension; left ventricular dysfunction; oedema; risk factors for cardiovascular events; ulcerative colitis (may be exacerbated).
Hepatic impairment: Max. 60 mg daily in mild impairment.
Max. 60 mg on alternate days or 30 mg once daily in moderate impairment.
Use with caution; there is an increased risk of gastro-intestinal bleeding and fluid retention.
Avoid in severe liver disease.
Renal impairment: The lowest effective dose should be used for the shortest possible duration.
Avoid if possible or use with caution.
With systemic use in adults: Avoid if eGFR less than 30 mL/minute/1.73 m2.
Use in Children: Avoid if estimated glomerular filtration rate less than 30 mL/ minute/1.73 m2.
In renal impairment monitor renal function; sodium and water retention may occur and renal function may deteriorate, possibly leading to renal failure.
Use in the Elderly: With systemic use: elderly (risk of serious side-effects and fatalities) (in adults).