Clinical data on escitalopram overdose are limited and many cases involve concomitant overdoses of other drugs. In the majority of cases mild or no symptoms have been reported. Fatal cases of escitalopram overdose have rarely been reported with escitalopram alone; the majority of cases have involved overdose with concomitant medications. Doses between 400 and 800 mg of escitalopram alone have been taken without any severe symptoms.
Treatment: There is no specific antidote. Establish and maintain an airway, ensure adequate oxygenation and respiratory function. Gastric lavage and the use of activated charcoal should be considered. Gastric lavage should be carried out as soon as possible after oral ingestion. Cardiac and vital signs monitoring are recommended along with general symptomatic supportive measures.
Monitor cardiac and vital signs along with general symptomatic and supportive measures. SSRI-induced seizers that fail to respond spontaneously may respond to diazepam.
Because of the large volume of distribution of SSRIs, forced diuresia, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit.