1 tab (containing estradiol 1 mg) daily during 14 consecutive days per cycle of 28 days and 1 tab (containing estradiol 1 mg and dydrogesterone 10 mg) daily during the remaining 14 days have to be taken. Immediately after 28-day cycle, the next treatment cycle is to be started.
If the patient is still menstruating, it is recommended to begin treatment on the 1st day after onset of menstruation.
If the patient is menstruating infrequently, it is advisable to begin treatment after 10-14 days monotherapy of progestogen ("chemical curettage").
In patients who had their last period more than a year ago, treatment can be started at any time.