Pharmacology: Pharmacodynamics: The active ingredient, estradiol, is chemically and biologically identical to the endogenous human estradiol and is, therefore, classified as a human estrogen.
Dydrogesterone is an orally active progestogen. Its activity is comparable to parenterally administered progesterone.
Pharmacokinetics: Following oral administration, micronized estradiol is readily absorbed and metabolized.
After oral administration, dydrogesterone is excreted into the urine. Excretion is complete within 72 hrs. No clinically relevant pharmacokinetic interactions occur between estradiol and dydrogesterone.