The dosage of Iron sucrose Injection is expressed in terms of mg of elemental iron.
Most Chronic Kidney Disease patients will require minimum cumulative dose of 1000 mg of elemental iron, administered over sequential sessions to achieve a favorable hemoglobin response and to replenish iron stores (ferritin, TSAT). Hemodialysis patients may continue to require therapy with Iron sucrose Injection or other intravenous iron preparations at the lowest dose necessary to maintain target levels of hemoglobin, and laboratory parameters of iron storage within acceptable limits.
Administration: Iron Sucrose Injection must only be administered intravenously either by slow injection or by infusion.
Recommended Adult Dosage: Heamodialysis Dependent-Chronic Kidney Disease Patients (HDD-CKD): Iron sucrose Injection may be administered undiluted as 100 mg slow intravenous injection over 2 to 5 minutes or as an infusion of 100 mg, diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes per consecutive hemodialysis session for a total cumulative dose of 1000 mg.
Non-Dialysis Dependent-Chronic Kidney Disease Patient (NDD-CKD): Iron sucrose Injection is administered as a total cumulative dose of 1000mg over a 14 day period as a 200mg slow IV injection undiluted over 2 to 5 minutes on 5 different occasions with in the 14 days period.
Peritoneal Dialysis Dependent-Chronic Kidney Disease Patients (PDD-CKD): Iron sucrose Injection is administered as a total cumulative dose of 1000 mg in 3 divided doses, given by slow intravenous infusion. Iron sucrose Injection dose should be diluted in a maximum of 250 mL of 0.9% NaCl.