Live Attenuated Virus Vaccines: Immunoglobulin administration may impair for a period of at least 6 weeks and up to 3 months the efficacy of live attenuated virus vaccines eg, measles, rubella, mumps and varicella. After administration of Flebogamma 5% DIF, an interval of 3 months should elapse before vaccination with live attenuated virus vaccines. In the case of measles, this impairment may persist for up to 1 year. Therefore, patients receiving measles vaccine should have their antibody status checked.
Interference with Serological Testing: After injection of immunoglobulin, the transitory rise of the various passively transferred antibodies in the patient's blood may result in misleading positive results in serological testing.
Passive transmission of antibodies to erythrocyte antigens eg, A, B, D, may interfere with some serological tests for red cell antibodies eg, the antiglobulin test (Coomb's test).
Incompatibilities: Flebogamma 5% DIF must not be mixed with other medicinal products or IV fluids. It should be administered by a separate IV line.