Flexbumin Indications/Uses

human albumin




Zuellig Pharma
Full Prescribing Info
Hypovolemia: Hypovolemia is a possible indication for FLEXBUMIN. Its effectiveness in reversing hypovolemia depends largely upon its ability to draw interstitial fluid into the circulation. It is most effective with patients who are well hydrated.
When hypovolemia is long standing and hypoalbuminemia exists accompanied by adequate hydration or edema, 20% and 25% albumin is preferable to 5% protein solutions. However, in the absence of adequate or excessive hydration, 5% protein solutions should be used or 20% and 25% albumin should be diluted with crystalloid.
Although crystalloid solutions and colloid-containing plasma substitutes can be used in emergency treatment of shock, Albumin (Human) has a prolonged intravascular half-life. When blood volume deficit is the result of hemorrhage, compatible red blood cells or whole blood should be administered as quickly as possible.
Hypoalbuminemia: General: Hypoalbuminemia is another possible indication for use of FLEXBUMIN.
Hypoalbuminemia can result from one or more of the following: Inadequate production (malnutrition, burns, major injury, infections, etc.).
Excessive catabolism (burns, major injury, pancreatitis, etc.).
Loss from the body (hemorrhage, excessive renal excretion, burn exudates, etc.).
Redistribution within the body (major surgery, various inflammatory conditions, etc.).
When albumin deficit is the result of excessive protein loss, the effect of administration of albumin will be temporary unless the underlying disorder is reversed. In most cases, increased nutritional replacement of amino acids and/or protein with concurrent treatment of the underlying disorder will restore normal plasma albumin levels more effectively than albumin solutions. Occasionally hypoalbuminemia accompanying severe injuries, infections or pancreatitis cannot be quickly reversed and nutritional supplements may fail to restore serum albumin levels. In these cases, FLEXBUMIN might be a useful therapeutic adjunct.
Burns: An optimum regimen for the use of albumin, electrolytes and fluid in the early treatment of bums has not been established, however, in conjunction with appropriate crystalloid therapy, FLEXBUMIN may be indicated for treatment of oncotic deficits after the initial 24 hour period following extensive bums and to replace the protein loss which accompanies any severe burn.
Adult Respiratory Distress Syndrome (ARDS): A characteristic of ARDS is a hypoproteinemic state, which may be causally related to the interstitial pulmonary edema. Although uncertainty exists concerning the precise indication of albumin infusion in these patients, if there is a pulmonary overload accompanied by hypoalbuminemia, 20% and 25% albumin solution may have a therapeutic effect when used with a diuretic.
Nephrosis: FLEXBUMIN may be a useful aid in treating edema in patients with severe nephrosis who are receiving steroids and/or diuretics.
Cardiopulmonary Bypass Surgery: FLEXBUMIN has been recommended prior to or during cardiopulmonary bypass surgery, although no clear data exist indicating its advantage over crystalloid solutions.
Hemolytic Disease of the Newborn (HDN): FLEXBUMIN may be administered in an attempt to bind and detoxify unconjugated bilirubin in infants with severe HDN.
There is no valid reason for use of albumin as an intravenous nutrient.
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