Fluanxol/Fluanxol Depot

Fluanxol/Fluanxol Depot

flupentixol

Manufacturer:

Lundbeck

Distributor:

B L Hua
Concise Prescribing Info
Contents
Flupentixol (Tab: diHCl; Inj: Cis(Z)-flupentixol decanoate)
Indications/Uses
Tab: Schizophrenia & allied psychoses eg, hallucinations, delusions & thought disturbances along w/ apathy, lack of energy, lowered mood & w/drawal. Inj: Schizophrenia & other related psychoses.
Dosage/Direction for Use
Tab Adult Schizophrenia & allied psychoses Individualized doses. Initially, 3-15 mg/day divided in 2 doses or 3 daily doses. Increase if necessary to 40 mg/day. Maintenance dose: 5-20 mg/day usually given as a single morning dose. Inj Adult 20 mg/mL, usually as 1-2 mL via IM inj & an interval of 1-4 wk. If needed >2 mL, divide between 2 inj site or 100 mg/mL about 1 mL (may vary between 0.5 mL & 4 mL), & the interval of 1-4 wk. If needed >2 mL, divide between 2 inj sites.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Tab: Circulatory collapse, depressed level of consciousness due to any cause (eg, intoxication w/ alcohol, barbiturates or opiates), coma. Inj: Diminished consciousness.
Special Precautions
Pregnancy & lactation. Tab: Neuroleptic malignant syndrome. Patients w/ organic brain syndrome, convulsion & advanced hepatic disease; susceptible individuals (w/ hypokalemia, hypomagnesia or genetic predisposition) & w/ history of CV disorders, recent acute MI, uncompensated heart failure or cardiac arrhythmia; risk factors for stroke. Antidiabetic therapy adjustment. Not recommended for excitable or overactive patients in doses up to 25 mg/day. Carefully monitor patients on long-term therapy, particularly on high doses & evaluate periodically. May cause QT prolongation. Avoid concomitant treatment w/ other antipsychotics. Closely monitor patients for depression & increased risk of suicidal thoughts, self-harm & suicide; history of suicide-related events, or those exhibiting significant degree of suicidal ideation prior to start of therapy. Venous thromboembolism. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. History of blood clots or are treated for cancer. Consider discontinuation if hyperprolactinaemia, galactorrhoea, amenorrhoea or sexual dysfunction occur. May impair general attention & conc in ability to drive or operate machinery. Childn. Elderly (increased risk of cerebrovascular events & risk of death). Inj: Liver problem; history of convulsion or fits, & CV disorders; diabetes; organic brain syndrome; risk factors of stroke; hypokalemia or hypomagnesia; other antipsychotic medicine; increased excitement or overactive; family history of blood clots; treated for cancer. Do not drive or use any tool or machines if feeling drowsy & dizzy. Childn & adolescents.
Adverse Reactions
Somnolence, akathisia, hyperkinesia, hypokinesia; dry mouth. Increased appetite, increased wt; insomnia, depression, nervousness, agitation, decreased libido; tremor, dystonia, dizziness, headache; accommodation disorder, abnormal vision; tachycardia, palpitations; dyspnoea; salivary hypersecretion, constipation, vomiting, dyspepsia, diarrhea; hyperhidrosis, pruritus; myalgia; micturition disorder, urinary retention; asthenia, fatigue.
Drug Interactions
May enhance sedative effect of alcohol, & effects of barbiturates & other CNS depressants. May increase or reduce the effect of antihypertensive drugs. Increased risk of neurotoxicity w/ lithium. Inhibit metabolism of TCAs. May reduce effect of levodopa & other adrenergic drugs. Increases risk of extrapyramidal symptoms w/ metoclopramide & piperazine. Increase in QT interval w/ Class Ia & III antiarrhythmics (eg, quinidine, amiodarone, sotalol, dofetilide), antipsychotics (eg, thioridazine), macrolides (eg, erythromycin), antihistamines (eg, terfenadine, astemizole), quinolone antibiotics (eg, gatifloxacin, moxifloxacin). May increase risk of QT prolongation & malignant arrhythmias w/ drugs known to cause electrolyte disturbances eg, thiazide diuretics & drugs known to increased plasma conc of flupentixol.
MIMS Class
ATC Classification
N05AF01 - flupentixol ; Belongs to the class of thioxanthene derivatives antipsychotics.
Presentation/Packing
Form
Fluanxol Depot inj 40 mg/2 mL
Packing/Price
10 × 1's
Form
Fluanxol tab 3 mg
Packing/Price
100's
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