Fluanxol: Combinations requiring precautions for use: Flupentixol may enhance the sedative effect of alcohol and the effects of barbiturates and other CNS depressants.
Neuroleptics may increase or reduce the effect of antihypertensive drugs; the antihypertensive effect of guanethidine and similar acting compounds is reduced.
Concomitant use of neuroleptics and lithium increases the risk of neurotoxicity.
Tricyclic antidepressants and neuroleptics mutually inhibit the metabolism of each other.
Flupentixol may reduce the effect of levodopa and the effect of adrenergic drugs.
Concomitant use of metoclopramide and piperazine increase the risk of extrapyramidal disorder.
Increases in the QT interval related to antipsychotic treatment may be exacerbated by the co-administration of other drugs known to significantly increase the QT interval. Co-administration of such drugs should be avoided. Relevant classes include: class Ia and III antiarrhythmics (e.g. quinidine, amiodarone, sotalol, dofetilide); some antipsychotics (e.g. thioridazine); some macrolides (e.g. erythromycin); some antihistamines (e.g. terfenadine, astemizole); some quinolone antibiotics (e.g. gatifloxacin, moxifloxacin).
The mentioned list is not exhaustive and other individual drugs known to significantly increase QT interval (e.g. cisapride, lithium) should be avoided.
Drugs known to cause electrolyte disturbances such as thiazide diuretics (hypokalemia) and drugs known to increase the plasma concentration of flupentixol should also be used with caution as they may increase the risk of QT prolongation and malignant arrhythmias (see Precautions).
Fluanxol Depot: Tell the doctor or pharmacist if the patient is taking, has recently taken or might take any other medicines.
Tell the doctor if the patient is taking any of the following medicines: Tricyclic antidepressant medicines; Guanethidine and similar medicines (used to lower the blood pressure); Barbiturates (medicines that make the patient feel drowsy); Medicines used to treat epilepsy; Levodopa and similar medicines (used to treat Parkinson's disease); Metoclopramide (used in the treatment of gastro-intestinal disorders); Piperazine (used in the treatment of roundworm and threadworm infections); Medicines that cause a disturbed water or salt balance (too little potassium or magnesium in the blood); Medicines known to increase the concentration of Fluanxol Depot in the blood.
The following medicines should not be taken at the same time as Fluanxol Depot: Medicines that change the heartbeat (quinidine, amiodarone, sotalol, dofetilide, erythromycin, terfenadine, astemizole, gatifloxacin, moxifloxacin, cisapride, lithium); Other antipsychotic medicines.
Fluanxol Depot with alcohol: Fluanxol Depot may increase the sedative effects of alcohol making the patient drowsier. It is recommended not to drink alcohol during treatment with Fluanxol Depot.