Fluanxol/Fluanxol Depot

Fluanxol/Fluanxol Depot Side Effects





B L Hua
Full Prescribing Info
Side Effects
Fluanxol Depot: Like all medicines, Fluanxol Depot can cause side effects, although not everybody gets them.
If the patient experiences any of the following symptoms, they should contact the doctor or go to the hospital straight away: Uncommon (in more than 1 out of 1,000 and less than 1 out of 100 persons): Unusual movements of the mouth and tongue; this may be an early sign of a condition known as tardive dyskinesia.
Very rare (in less than 1 out of 10,000 persons): High fever, unusual stiffness of the muscles and disorder of consciousness, especially if occurring with sweating and fast heart rate; these symptoms may be signs of a rare condition called neuroleptic malignant syndrome which has been reported with the use of different antipsychotics.
Yellowing of the skin and the white in the eyes, this may mean that the liver is affected and a sign of a condition known as jaundice.
The following side effects are most pronounced in the beginning of the treatment and most of them usually wear off during continued treatment: Very common (in 1 or more out of 10 persons): Sleepiness (somnolence), inability to sit still or remain motionless (akathisia), involuntary movements (hyperkinesia), slow or diminished movements (hypokinesia); Dry mouth.
Common (in more than 1 out of 100 persons and less than 1 out of 10 persons): Racing heart (tachycardia), a sensation of a rapid, forceful, or irregular beating of the heart (palpitations); Tremor, twisting or repetitive movements or abnormal postures due to sustained muscle contractions (dystonia), dizziness, headache; Difficulties focusing on objects near to the eye (accommodation disorder), vision abnormalities; Difficulty breathing or painful breathing (dyspnoea); Increased saliva secretion (salivary hypersecretion), constipation, vomiting, digestive problems or discomfort centered in the upper abdomen (dyspepsia), diarrhoea; Urination disorder (micturition disorder), lack of ability to urinate (urinary retention); Increased sweating (hyperhidrosis), itching (pruritus); Muscle pain (myalgia); Increased appetite, increased weight; Fatigue, weakness (asthenia); Sleeplessness (insomnia), depression, nervousness, agitation, decreased sexual drive (libido decreased).
Uncommon (in more than 1 out of 1,000 and less than 1 out of 100 persons): Jerky movements (dyskinesia), parkinsonism, speech disorder, convulsion; Circular movement of the eye (oculogyration); Abdominal pain, nausea, flatulence; Rash, skin reaction due to sensitivity to light (photosensitivity reaction), eczema or inflammation of the skin (dermatitis); Muscle rigidity; Decreased appetite; Low blood pressure (hypotension), hot flush; Red or sore skin where the Fluanxol Depot injection was given; Abnormal liver function tests; Sexual disturbance (delayed ejaculation, problems with erection); State of confusion.
Rare (more than 1 out of 10,000 and less than 1 out of 1,000 persons): Low blood platelet count (thrombocytopenia), low white blood platelet count (neutropenia), reduced white blood cell count (leukopenia), bone marrow poisoning (agranulocytosis); Increased level of prolactin in the blood (hyperprolactinaemia); High blood sugar (hyperglycaemia), abnormal glucose tolerance; Over-sensitivity (hypersensitivity), acute systemic and severe allergic reaction (anaphylactic reaction); Development of breasts in men (gynaecomastia), excessive milk production (galactorrhoea), lack of menstrual periods (amenorrhoea).
As with other medicines that work in a way similar to flupentixol decanoate (the active ingredient of Fluanxol Depot), rare cases of the following side effects have been reported: QT prolongation (slow heart beat and change in the ECG); Irregular heart beat (ventricular arrhythmias, ventricular fibrillation, ventricular tachycardia); Torsades de Pointes (a special kind of irregular heart beat).
In rare cases irregular heart beats (arrhythmias) may have resulted in sudden death.
Blood clots in the veins especially in the legs (symptoms include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing. If the patient notices any of these symptoms the patient should seek medical advice immediately.
In elderly people with dementia, a small increase in the number of deaths has been reported for patients taking antipsychotics compared with those not receiving antipsychotics.
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