Flutan

Flutan

flutamide

Manufacturer:

Medochemie

Distributor:

F.C.P.
Concise Prescribing Info
Contents
Flutamide
Indications/Uses
Advanced prostatic carcinoma in which suppression of testosterone effects is indicated: initial treatment in combination w/ an LHRH agonist; as adjunctive therapy in patients already receiving an LHRH agonist; in surgically castrated patients; in the treatment of patients nonresponsive or intolerant to other forms of hormonal manipulation. For the management, in combination w/ LHRH agonists, of locally confined B2-C2 (T2b-T4) prostate carcinoma as initial therapy, bulky primary tumours confined to the prostate (stage B2 or T2b) or extending beyond the capsule (stage C or T3-T4), w/ or w/o pelvic node involvement.
Dosage/Direction for Use
For male patients only. Adult 250 mg 8 hrly. Initially treatment w/ an LHRH agonist for the management of locally confined prostatic carcinoma Flutamide administration should start at least 3 days before LHRH agonist administration. Administration of flutamide & the LHRH agonist should start 8 wk before radiation therapy course for a total of about 16 wk.
Administration
May be taken with or without food.
Contraindications
Hepatic impairment.
Special Precautions
Periodic liver function tests required. Periodic sperm count determination may be considered w/ long-term treatment. Cardiac disease. Sexually active patients should use additional barrier contraception eg, condom. May impair ability to drive or operate machinery.
Adverse Reactions
Hepatic dysfunction (discontinue). Gynaecomastia, breast tenderness, galactorrhoea. Less frequently, appetite increase, diarrhoea, insomnia, nausea, fatigue, vomiting, transient abnormal liver function, hepatitis. Rarely, anorexia, anxiety, chest pain, constipation, depression, dizziness, ecchymoses, headache, heartburn, herpes zoster, libido decline, lupus-like syndrome, lymphoedema, malaise, oedema, pruritus, stomach upset, ulcer-like pain, vision blurring, weakness, decreased sperm count.
Drug Interactions
Warfarin.
ATC Classification
L02BB01 - flutamide ; Belongs to the class of anti-androgens. Used in treatment of neoplastic diseases.
Presentation/Packing
Form
Flutan tab 250 mg
Packing/Price
10 × 10's
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