Fluzoral

Fluconazole

Treatment of oropharyngeal, esophageal, vulvovag candidiasis & other serious systemic candidal infections (eg, UTI, peritonitis, candidemia, disseminated candidiasis, meningitis, pneumonia); cryptococcosis caused by Cryptococcus neoformans including meningitis & infections of other sites. Prophylaxis of serious fungal infections in patient w/ HIV infections or receiving cytotoxic chemotherapy &/or radiation therapy.

Oropharyngeal candidiasis Adult & elderly Single 200-mg dose on the 1st day then 100 or 200 mg once daily for at least 2 wk. Childn ≥6 mth 6 mg/kg on the 1st day then 3 mg/kg once daily for a min of 2 wk. Esophageal candidiasis Adult & elderly Single 200-mg dose on the 1st day then 100 or 200 mg once daily for a min of 3 wk & for at least 2 wk after symptoms have resolved. Childn ≥6 mth 6 mg/kg on the 1st day then 3 mg/kg once daily for a min of 3 wk & for at least 2 wk after symptoms have resolved; may be increased up to 12 mg/kg once daily if necessary. Vulvovag candidiasis Adult & elderly Single 150-mg dose for 1 day only. Systemic candidiasis Adult & elderly Single 400-mg dose on the 1st day then 200 mg once daily for a min of 4 wk & for at least 2 wk after symptom have resolved. Childn ≥6 mth 6-12 mg/kg daily. Cryptococcal meningitis Adult & elderly Single 400-mg dose on the 1st day then 200-400 mg once daily for 10-12 wk after CSF is sterile. Childn ≥6 mth 12 mg/kg on the 1st day then 6 mg/kg daily for 10-12 wk after CSF becomes culture-negative; may be increased to 12 mg/kg daily if necessary. For suppressive or maintenance therapy to prevent recurrence or relapse of cryptococcal meningitis in patient w/ HIV infection Adult & elderly 200 mg once daily. Childn ≥6 mth 3-6 mg once daily. Prevention of candidiasis in patient w/ cancer Adult & elderly 400 mg once daily. Tinea corporis, cruris or pedis Adult & elderly 150 mg once wkly or 50 mg once daily for 2-6 wk.

May be taken with or without food.

Hypersensitivity to fluconazole or other azole compd. Co-administration of a ≥400 mg/day dose w/ terfenadine. Childn <6 mth. Pregnancy, lactation.

Hepatic & renal impairment, history of alcoholism. Discontinue if signs & symptoms of liver disease develop. Monitor for development of more severe hepatic injury. Discontinue if rashes develop & lesions progress in immunocompromised patients.

Mild to moderate nausea, vomiting, abdominal pain, diarrhea.

Warfarin, tolbutamide, glyburide, glipizide or other sulfonylureas, hydrochlorothiazide, cyclosporine, theophylline, terfenadine, phenytoin.

Antifungals

J02AC01 - fluconazole ; Belongs to the class of triazole derivatives. Used in the systemic treatment of mycotic infections.

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