Fluzoral

Fluzoral

fluconazole

Manufacturer:

GPO

Distributor:

GPO
Concise Prescribing Info
Contents
Fluconazole
Indications/Uses
Treatment of oropharyngeal, esophageal, vulvovag candidiasis & other serious systemic candidal infections (eg, UTI, peritonitis, candidemia, disseminated candidiasis, meningitis, pneumonia); cryptococcosis caused by Cryptococcus neoformans including meningitis & infections of other sites. Prophylaxis of serious fungal infections in patient w/ HIV infections or receiving cytotoxic chemotherapy &/or radiation therapy.
Dosage/Direction for Use
Oropharyngeal candidiasis Adult & elderly Single 200-mg dose on the 1st day then 100 or 200 mg once daily for at least 2 wk. Childn ≥6 mth 6 mg/kg on the 1st day then 3 mg/kg once daily for a min of 2 wk. Esophageal candidiasis Adult & elderly Single 200-mg dose on the 1st day then 100 or 200 mg once daily for a min of 3 wk & for at least 2 wk after symptoms have resolved. Childn ≥6 mth 6 mg/kg on the 1st day then 3 mg/kg once daily for a min of 3 wk & for at least 2 wk after symptoms have resolved; may be increased up to 12 mg/kg once daily if necessary. Vulvovag candidiasis Adult & elderly Single 150-mg dose for 1 day only. Systemic candidiasis Adult & elderly Single 400-mg dose on the 1st day then 200 mg once daily for a min of 4 wk & for at least 2 wk after symptom have resolved. Childn ≥6 mth 6-12 mg/kg daily. Cryptococcal meningitis Adult & elderly Single 400-mg dose on the 1st day then 200-400 mg once daily for 10-12 wk after CSF is sterile. Childn ≥6 mth 12 mg/kg on the 1st day then 6 mg/kg daily for 10-12 wk after CSF becomes culture-negative; may be increased to 12 mg/kg daily if necessary. For suppressive or maintenance therapy to prevent recurrence or relapse of cryptococcal meningitis in patient w/ HIV infection Adult & elderly 200 mg once daily. Childn ≥6 mth 3-6 mg once daily. Prevention of candidiasis in patient w/ cancer Adult & elderly 400 mg once daily. Tinea corporis, cruris or pedis Adult & elderly 150 mg once wkly or 50 mg once daily for 2-6 wk.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to fluconazole or other azole compd. Co-administration of a ≥400 mg/day dose w/ terfenadine. Childn <6 mth. Pregnancy, lactation.
Special Precautions
Hepatic & renal impairment, history of alcoholism. Discontinue if signs & symptoms of liver disease develop. Monitor for development of more severe hepatic injury. Discontinue if rashes develop & lesions progress in immunocompromised patients.
Adverse Reactions
Mild to moderate nausea, vomiting, abdominal pain, diarrhea.
Drug Interactions
Warfarin, tolbutamide, glyburide, glipizide or other sulfonylureas, hydrochlorothiazide, cyclosporine, theophylline, terfenadine, phenytoin.
MIMS Class
ATC Classification
J02AC01 - fluconazole ; Belongs to the class of triazole derivatives. Used in the systemic treatment of mycotic infections.
Presentation/Packing
Form
Fluzoral cap 200 mg
Packing/Price
5 × 10's
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