Symptoms of tiredness may sometimes appear, especially at the beginning of treatment and when higher doses are used. Also in rare instances, and usually only temporarily, the patient may experience dryness of the mouth, constipation, loss of appetite, nausea, dizziness or a fine tremor of the fingers. Another possibility is the emergence of paradoxical reactions (eg, restlessness, irritability, acute agitational states, anxiety, suicidal tendencies, frequent muscle spasms, difficulty in falling asleep and to sleep through).
In the event of such reactions, treatment with Frisium should be discontinued.
Slowing of reaction time, ataxia, drowsiness, confusion and headaches may occasionally occur.
Cutaneous reactions eg, eruptions or urticaria have been observed in isolated cases.
Impairment of respiratory function may become manifest in certain diseases of the respiratory passages (airways obstruction eg, in bronchial asthma) and in patients with brain damage.
After prolonged use of benzodiazepines, impairment of consciousness sometimes combined with respiratory disorders, has been reported in very rare cases, particularly in elderly patients; it sometimes persists for some length of time.
Especially in patients receiving high doses or long-term treatment, there may be reversible abnormalities eg, slowing or indistinctness of speech (disorders of articulation), lack of confidence in walking and other motor functions, visual disorders (double vision, nystagmus), weight gain or loss of libido.
When used as an adjuvant in the treatment of epilepsy, Frisium occasionally causes restlessness and muscle weakness.
As with other drugs of this type (benzodiazepines), the therapeutic benefit must be balanced against the risk of habituation and dependence during prolonged use (see under Precautions). Should any adverse reactions occur, consult a physician.