Furosemide GPO

Furosemide GPO





Full Prescribing Info
Tablet: Each tablet contains: Furosemide 40 mg.
Injection: Each 2 ml contains Furosemide 20 mg.
Edema associated with congestive heart failure, hepatic cirrhosis, and renal disease (including nephrotic syndrome).
Tablet: Hypertension, mild to moderate.
Injection: Acute pulmonary edema; as an adjunctive therapy.
Hypertensive crisis; as an adjunctive treatment.
Hypercalcemia, to increase renal excretion of calcium.
Dosage/Direction for Use
Tablet: Adults: 1/2-2 tablets (20-80 mg) 1-2 times daily, as directed by the physician.
Children: 2 mg/kg body weight once daily.
Injection: Adults: Edema: IV or IM, initially 20-40 mg as a single dose. If diuretic effects is not satisfactory the dosage then being increased by an additional 20 mg every 2 hours until the desired response is obtained. The effective dose is then be given once or twice daily.
Acute pulmonary edema: The usual initial dose is 40 mg slowly injected IV over 1-2 minutes followed by 80 mg in one hour if a satisfactory response is not obtained.
Hypertensive crisis: IV 40-80 (administered concomitantly with other hypotensive drugs); in patients with reduced renal function higher dosage may be required.
Note: Geriatric patients may be more sensitive to the effects of the usual adult dose.
Children and Infants: IV or IM, initially 1 mg/kg as a single dose. If necessary, the dosage may be increased by an additional 1 mg/kg not more than 2-hour intervals until the desired response is obtained, but not exceed a maximum of 6 mg/kg.
Note: Furosemide injection is indicated when a rapid onset of diuresis is desired or the patients is unable to take oral medication. The injection should be replaced by oral preparation as soon as possible.
IV injection is generally preferred over IM injection.
IV injection should be given slowly over 1-2 minutes. If high dose is required, the drug should be administered as a controlled infusion at the rate not exceeding 4 mg/min in adults. The infusion solution should be freshly prepared and used within 24 hours.
Furosemide injection is mildly buffered alkaline solution and should not be mixed with highly acidic solutions nor with other drugs in the same syringe.
In patients with known hypersensitivity to the drug or to sulfonamides, patients with anuria, severe impaired renal function, hepatic coma, and electrolyte depletion.
Special Precautions
Notify physician if signs and symptoms of electrolyte depletion and/or excessive diuresis occur (e.g., weakness, dizziness, fatigue, faintness, mental confusion, muscle cramps, headache, nausea, and/or vomiting).
A potassium-rich diet, or potassium supplements may be necessary before and during furosemide therapy to prevent hypokalemia in cirrhotic, nephrotic, or digitalized patients.
Periodical determination of serum electrolytes, blood glucose, blood urea nitrogen, and blood cholesterol during furosemide therapy are recommended.
Use with caution in patients with hepatic or renal disorders, hepatic cirrhosis, diabetes mellitus and gout.
Caution when concomitantly used with other drugs such as parenteral amphotericin B, oral anticoagulants, hypokalemia-causing drugs, lithium, antidiabetic drugs, digitalis glycosides, aminoglycoside antibiotics, and other ototoxic and nephrotoxic drugs.
Use in Pregnancy & Lactation: Furosemide should not be used during pregnancy unless necessary and must be administered only for a short period of time. Breast feeding should be discontinued when the drug is used in nursing women.
Use In Pregnancy & Lactation
Furosemide should not be used during pregnancy unless necessary and must be administered only for a short period of time. Breast feeding should be discontinued when the drug is used in nursing women.
Side Effects
Fluid and electrolyte imbalance occurs frequently, especially after prolonged use. Orthostatic hypotension, hemoconcentration and circulatory collapse result from excessive hydration are likely to occur in geriatric patients.
Furosemide increases calcium excretion; rarely, tetany has been reported.
Other effects rarely occur include hyperuricemia, hyperglycemia, hypercholesterolemia, nausea, vomiting, diarrhea, dizziness, headache, photosensitivity, rash and urticaria.
Store below 25°C, protect from light.
MIMS Class
ATC Classification
C03CA01 - furosemide ; Belongs to the class of high-ceiling sulfonamide diuretics.
Tab 40 mg x 500's. Inj (amp) 20 mg/2 mL x 50 x 1's.
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in