All signs that worry a patient should be reported to a physician. If severe hypoglycaemia or hyperglycaemia and ketoacidosis symptoms occur, an immediate medical help is necessary.
The most frequent adverse effects in insulin treatment include: Hypoglycaemia (drop in glucose concentration in blood).
Symptoms of hypoglycaemia are: Over-sweating, dizziness, trembling, sensation of hunger, anxiety, tingling sensation in hands, feet and lips or tongue, concentration disturbances, sleepiness, sleep disturbances, loss of self-control, mydriasis, visual disorders, speech disturbances, depression, irritability. Symptoms of acute hypoglycaemia are: Disorientation, unconsciousness, convulsions.
Hyperglycaemia (increase of glucose concentration in blood): In patients suffering from type one diabetes prolonged hyperglycaemia leads to ketoacidosis and diabetes coma, which is life-threatening. First ketoacidosis symptoms that gradually appear within hours, or even days, are: Sleepiness, reddening of the face, thirst, loss of appetite, acetone-like smell of the breathed out by the ill air, increased amount of glucose and ketone bodies, fast breath and heart beat. Other adverse events that occasionally occur during biosynthetic insulin treatments are: Post-insulin lypodystrophy (atrophy or over-growth of fat tissue in the area of puncture), allergy to insulin, insulin resistance.