Insulin Glargine is not intended for intravenous administration. Intravenous administration of the usual subcutaneous dose could result in severe hypoglycemia. Insulin Glargine is not the insulin of choice for the treatment of diabetic ketoacidosis. Instead, intravenous regular insulin is recommended in such cases.
Renal Impairment: In patients with renal impairment, insulin requirements may be diminished. In the elderly, progressive deterioration of renal function may lead to a steady decrease in insulin requirements.
Hepatic Impairment: In patients with severe hepatic impairment, insulin requirements may be diminished due to reduced capacity for gluconeogenesis and reduced Insulin metabolism.
Intercurrent Conditions: Insulin requirements may be altered during intercurrent conditions such as illness, emotional disturbances or stress.