Glibenclamide and Metformin are combined together in this medicine.
Glibenclamide+Metformin is used to treat type 2 diabetes by keeping your blood sugar in control.
This medicine is meant to be used as part of a complete diabetes care programme that should include exercise, a healthy diet and regular monitoring of blood sugar levels.
Take Glibenclamide+Metformin exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Take it together with food or immediately after a meal. Try to take it at the same time each day.
Glibenclamide+Metformin must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to take your medicine, let your doctor and pharmacist know.
Alert your doctor if you have the following conditions:
- severe kidney disease
- serious complication of diabetes such as metabolic acidosis (e.g. lactic acidosis, diabetic ketoacidosis)
as this medicine may not be suitable for you.
Do not take Glibenclamide+Metformin with medicines for high blood pressure. Please see the section “Can I take this with other medicines?” below for more information.
Inform your doctor if you have the following conditions:
- G6PD deficiency (an inherited blood disorder that affects the red blood cell)
- heart failure (weakness and inability of the heart to pump blood)
- liver disease
Let your doctor know if you are pregnant or breastfeeding.
Notify your doctor if you consume large amounts of alcohol or if you are a frequent drinker.
If you are going for an operation, including minor surgery, dental work or any examination which involves an injection of contrast medicine that contains iodine such as x-ray, inform your doctor or dentist that you are taking Glibenclamide+Metformin.
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- Routine urine tests for glucose and ketones will be done while you are being treated with this medicine.
- Monitoring of vitamin B12 and folate level, liver and kidney function may also be needed.
Your doctor will advise you about how often you need to have these tests.
You may have been warned about hypoglycaemia. Hypoglycaemia is the medical term for low blood sugar. It is important for you to recognise the symptoms of hypoglycaemia and correct the low blood sugar level. If you don't, you may faint.
How do I know if I am experiencing hypoglycaemia?
Some of the symptoms of hypoglycaemia include dizziness, headache, shaky hands, feeling hungry, weak or confused, problems speaking. These symptoms are your body's way of warning you that your blood sugar is dangerously low.
What should I do if I am experiencing hypoglycaemia?
You should take a drink or food containing sugar (e.g. fruit juice, soft drinks, sweets) at the first sign of hypoglycaemia. If your symptoms do not improve, get medical help. Keep some glucose tablets (also known as dextrose tablets) with you at all times.
Glibenclamide+Metformin may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects include any of the following: headache, upper airway infection (e.g. runny or stuffy nose, sneezing, coughing, sore throat), nausea, vomiting, diarrhoea and stomach pain.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- signs of lactic acidosis (build up of acid in the blood) such as general feeling of discomfort, illness or uneasiness, muscle pain, difficulty in breathing, drowsiness, stomach pain
- signs of hypoglycaemia
- signs and symptoms of liver problems such as yellowing of the skin or eyes, dark coloured urine, feeling weak or tired, loss of appetite, stomach pain
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not take Glibenclamide+Metformin if you are taking medicinea for heart disease e.g. bosentan.
Inform your doctor and pharmacist if you are taking any of these medicines:
- medicines to treat fungal infection e.g. miconazole
- water pill e.g. furosemide
- medicines for epilepsy (fits or seizures) e.g. phenytoin
- blood-thinning medicines e.g. aspirin, warfarin
- medicines for heart disease e.g. nifedipine
- medicines for gout e.g. probenecid
- stomach medicines e.g. cimetidine
- medicines to treat depression e.g. isocarboxacid, phenelzine, tranylcypromine
This list does not include all medicines that may interact with Glibenclamide+Metformin.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.