Gastrointestinal disturbances: Nausea, diarrhoea, gastric pain, constipation, vomiting, metallic taste in mouth.
Dermatological effects: Rash, pruritus, urticaria, erythema and flushing.
Miscellaneous: Headache and dizziness.
Gliclazide appears to be associated with a low incidence of hypoglycaemia.
Gliclazide has been an established agent for the treatment of Type II diabetes mellitus for a number of years without adverse cardiovascular effects. Impaired gastrointestinal absorption of vitamin B12 and folic acid has been associated with long term metformin therapy.