Glypressin

Glypressin

terlipressin

Manufacturer:

Ferring

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Terlipressin acetate
Indications/Uses
Bleeding oesophageal varices & type 1 hepatorenal syndrome in patients suffering from severe cirrhosis w/ ascites.
Dosage/Direction for Use
Adult Bleeding oesophageal varices Initially 2 mg IV 4 hrly until bleeding is controlled, up to 24-48 hr. Patients weighing <50 kg Dose adjustment after initial dose: 1 mg IV 4 hrly. Type 1 hepatorenal syndrome 3-4 mg 24 hrly as 3 or 4 administrations until a serum creatinine of <130 mmol/L or a drop of at least 30% is reached. Duration of treatment: 10 days.
Contraindications
Special Precautions
Monitor BP, heart rate & fluid balance during treatment. Patients w/ HTN or heart disease. Do not use in patients w/ septic shock w/ low cardiac output. Lactation. Childn & elderly.
Adverse Reactions
Paleness, increased BP, abdominal pain, nausea, diarrhea, headache. Bradycardia; peripheral vasoconstriction, peripheral ischemia, facial pallor, HTN; transient abdominal cramps, transient diarrhoea.
Drug Interactions
Increase hypotensive effect of non-selective β-blockers. Heart rate & cardiac output may be lowered w/ drugs w/ known bradycardic effect eg, propofol & sufentanil.
ATC Classification
H01BA04 - terlipressin ; Belongs to the class of vasopressin and analogues. Used in posterior pituitary lobe hormone preparations.
Presentation/Packing
Form
Glypressin soln for inj 1 mg/8.5 mL
Packing/Price
5 × 1's
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