Ear, nose, throat, skin, & GUT infections Adult & childn over 12 yr 500 mg every 12 hr or 250 mg every 8 hr. Dose may be increased to 500 mg every 8 hr in severe infection. Duration of therapy: Continue for at least 2-3 days after patient becomes asymptomatic. Gonorrhea Single 3 g oral dose. Prevention of bacterial endocarditis Single 2 g oral dose given 1 hr before dental procedure or minor upper resp tract surgery or instrumentation.
History of allergy, impaired renal function. Periodic determination of renal, hepatic & hemopoietic function during prolonged therapy is recommended. Discontinue use if skin rashes, itching or edema, flu-like syndrome, Stevens-Johnson syndrome, blistering, peeling skin & conjunctivitis. May cause anaphylactic reactions. Pregnancy & lactation.
Synergistic effect against β-lactamase producing bacteria w/ clavulanic acid. May decrease renal secretion of methotrexate. Increase serum results in GI or hematologic toxicity of methotrexate. Slowed rate of renal secretion w/ oral probenecid (if administered shortly before amoxicillin). Potentiated aminopenicillin allergy may occur w/ allopurinol.