GPO Mox Mechanism of Action





Full Prescribing Info
Pharmacology: Pharmacodynamics: Amoxicillin is active against various gram-positive and gram-negative bacteria including Streptococci, Haemophilus influenza, Proteus mirabilis, Escherichia coli, and Neisseria spp. Amoxicillin is inactivated by penicillinase.
Pharmacokinetics: Amoxicillin is readily absorbed when administered orally. Food does not interfere with its absorption. It is more completely absorbed than ampicillin and is reported to peak antibiotic plasma concentration that are up to 2½ times as high as those from the same dose of ampicillin. Peak plasma concentration of about 3.5-5 μg/ml or 5.5-11 μg/ml have been observed 1-2 hours after a dose of 250 mg or 500 mg respectively. It is 17-20% bound to plasma protein. The elimination half-life is 0.7-1.4 hours. Most of the dose is excreted unchanged in the urine by tubular excretion, therefore probenecid can delay its excretion.
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