Use in Pregnancy: Safe use of amoxicillin during pregnancy has not been definitely established. There are no adequate or controlled studies using amoxicillin in pregnant women, and amoxicillin should be used during pregnancy only when clearly needed. However, amoxicillin has been administered to pregnant women without evidence of adverse effects to the fetus. It is the drug of choice for the treatment of chlamydial infections in pregnancy and for the treatment and for postexposure prophylaxis of anthrax following exposure to Bacillus anthracis spores.
Use in Lactation: Because amoxicillin is distributed into milk and may lead to sensitization of infants, the drug should be used with caution in nursing women. Amoxicillin is an option for anti-infective prophylaxis in breast-feeding woman when Bacillus anthracis is susceptible to penicillin.