Grendis

Grendis

triflusal

Manufacturer:

J. Uriach

Distributor:

Zuellig Pharma

Marketer:

Abbott
Full Prescribing Info
Contents
Triflusal.
Action
Grendis is a platelet aggregation inhibitor, which prevent blood vessels from being obstructed by blood clots or thrombi.
Indications/Uses
To reduce the risk of recurrent myocardial infarction, stable or unstable angina or stroke in patients who have previously had any of these events. Also indicated in patients who have undergone coronary bypass surgery.
Dosage/Direction for Use
Adults: 2 caps (triflusal 600 mg)/day, as a single dose or in 2 divided doses, or 3 caps (triflusal 900 mg)/day in 3 divided doses.
Swallow the capsule with a sufficient quantity of liquid, preferably with meals.
Missed Dose: A double dose must not be taken to make up for missed individual doses. Continue to take Grendis as is usual.
Overdosage
After ingesting large doses of Grendis, symptoms of salicylate intoxication may appear (headache, tinnitus, vertigo, nausea, vomiting, accelerated breathing).
In case of overdose or accidental ingestion, the doctor or pharmacist should be informed.
Contraindications
Allergy to triflusal or other salicylates. Stomach ulcer, any other disorder that may cause bleeding.
Special Precautions
Caution in patients who suffer from kidney or liver insufficiency; exposed to bleeding risk, due to an injury or other pathological conditions, or long-term NSAID therapy. If patient will undergo any surgical operation, the bleeding risk must be evaluated and if necessary, Grendis should be discontinued 7 days prior to surgery.
Effects on the Ability to Drive or Operate Machinery: Grendis has no effect of the ability to drive or use machines.
Side Effects
The most common side effect is heaviness of stomach. Headache, abdominal pain, nausea, constipation, vomiting, flatulence or diarrhea may also appear. These symptoms are usually mild and disappear within a few days without interrupting treatment. By taking Grendis with meals, the possibility of GI effects decreases. Occasionally, GI bleeding, blood in urine, bruising, nose bleeds, gum bleeds or cerebral hemorrhage have been observed. There have also been some isolated cases of photosensitivity.
Drug Interactions
NSAIDs, oral antidiabetics or oral anticoagulants may intensify the effects of Grendis.
Storage
Do not store above 25°C.
ATC Classification
B01AC18 - triflusal ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.
Presentation/Packing
Cap 300 mg x 30's.
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