The expected in vivo
peak antihemophilic factor level, expressed as IU/dL of plasma or % of normal, can be calculated by multiplying the dose administered per kg body wt (IU/kg) by 2 eg, a peak level of 70% is required in a 40-kg child: Dose should be 70/2 x 40 = 1,400 IU. IV infusion Early hemarthrosis or muscle/oral bleed
20-40% of normal plasma every 12-24 hr for 1-3 days. More extensive hemarthrosis, muscle bleed or hematoma
30-60% of normal plasma every 12-24 hr for ≥3 days. Life-threatening bleeds eg, head injury, throat bleed, severe abdominal pain
60-100% of normal plasma every 8-24 hr. Minor surgery (including tooth extraction)
60-80% of normal plasma single infusion w/in 1 hr. Major surgery (pre- & post-op)
80-100% of normal plasma every 8-24 hr.