Concise Prescribing Info
Acute bacterial exacerbations of COPD, acute bacterial sinusitis & acute otitis media caused by H. influenzae, M. catarrhalis, S. pneumoniae. Community-acquired pneumonia (CAP) caused by H. influenzae, M. pneumoniae, S. pneumoniae, Chlamydophila pneumoniae. Genital ulcer disease (chancroid) in men caused by Haemophilus ducreyi. Pharyngitis/tonsillitis caused by S. pyogenes. Uncomplicated skin & skin structure infections caused by S. aureus, S. pyogenes, Strep agalactiae. Urethritis & cervicitis caused by Chlamydia trachomatis, Neisseria gonorrhoeae.
Dosage/Direction for Use
Adult Acute bacterial exacerbations of COPD (mild to moderate severity) Usual dose: 500 mg/day for 3 days; alternative dose: 500 mg as single dose on the 1st day followed by 250 mg once daily on days 2-5. Acute bacterial sinusitis 500 mg/day for 3 days. CAP (mild severity), pharyngitis/tonsillitis (as 2nd-line therapy), uncomplicated skin/skin structure infections 500 mg as single dose on the 1st day followed by 250 mg once daily on days 2-5. Genital ulcer disease (chancroid), non-gonococcal urethritis/cervicitis 1 g as single dose. Gonococcal urethritis/cervicitis 2 g as single dose. Childn ≥2 yr Pharyngitis/tonsillitis Usual dose: 12 mg/kg once daily for 5 days. Max dose: 500 mg/day, ≥6 mth Acute bacterial sinusitis 10 mg/kg once daily for 3 days. Acute otitis media Usual dose: 30 mg/kg as single dose; alternative dose: 10 mg/kg once daily for 3 days or 10 mg/kg as single dose on the 1st day followed by 5 mg/kg on days 2-5. CAP 10 mg/kg as single dose on the 1st day followed by 5 mg/kg on days 2-5.
May be taken with or without food.
Hypersensitivity to azithromycin or other macrolide antibiotics.
Special Precautions
Hypersensitivity. May cause liver damage. Discontinue in symptoms of malaise, nausea, vomiting abdominal colic & fever. Reappearance of allergic reaction. May mask or delay symptoms of incubating gonorrhea or syphilis; perform appropriate culture & susceptibility tests prior to initiating treatment. Prolonged use may result in fungal or bacterial superinfection, eg, C. difficile-associated diarrhea & pseudomembranous colitis. Patients at risk of prolonged cardiac repolarization; w/ myasthenia gravis; preexisting liver disease; hepatic impairment w/ or w/o jaundice. Renal dysfunction; patients w/ GFR <10 mL/min. Pregnancy & lactation.
Adverse Reactions
Diarrhea, nausea, abdominal pain, anorexia, cramping, vomiting, oral candidiasis; pruritus, rash; vaginitis, acute renal failure; arrhythmias, hypotension; aggressive reaction, anxiety, hyperactivity, paresthesia, syncope; thrombocytopenia; cholestatic jaundice; hearing disturbances (eg, deafness &/or tinnitus), taste loss & smell perversion; arthralgia, edema.
Drug Interactions
Avoid concomitant use w/ artemether, BCG, dronedarone, lumefantrine, nilotinib, pimozide, quinine, tetrabenazine, thioridazine & ziprasidone. May increase effects of cardiac glycosides, cyclosporine, dronedarone, pimozide, QTc-prolonging agents, quinine, tacrolimus, tetrabenazine, thioridazine, vit K antagonist & ziprasidone. Effect may be increased by alfuzosin, artemether, chloroquine, ciprofloxacin, conivaptan, gadobutrol, lumefantrine, nilotinib & quinine. May decrease effects of BCG & typhoid vaccine.
MIMS Class
ATC Classification
J01FA10 - azithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.
Hofmax cap 250 mg
1 × 6's
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