Hofmax

Hofmax

azithromycin

Manufacturer:

Pharmahof

Distributor:

Pharmahof
Concise Prescribing Info
Contents
Azithromycin
Indications/Uses
Acute bacterial exacerbations of COPD, acute bacterial sinusitis & acute otitis media caused by H. influenzae, M. catarrhalis, S. pneumoniae. Community-acquired pneumonia (CAP) caused by H. influenzae, M. pneumoniae, S. pneumoniae, Chlamydophila pneumoniae. Genital ulcer disease (chancroid) in men caused by Haemophilus ducreyi. Pharyngitis/tonsillitis caused by S. pyogenes. Uncomplicated skin & skin structure infections caused by S. aureus, S. pyogenes, Strep agalactiae. Urethritis & cervicitis caused by Chlamydia trachomatis, Neisseria gonorrhoeae.
Dosage/Direction for Use
Adult Acute bacterial exacerbations of COPD (mild to moderate severity) Usual dose: 500 mg/day for 3 days; alternative dose: 500 mg as single dose on the 1st day followed by 250 mg once daily on days 2-5. Acute bacterial sinusitis 500 mg/day for 3 days. CAP (mild severity), pharyngitis/tonsillitis (as 2nd-line therapy), uncomplicated skin/skin structure infections 500 mg as single dose on the 1st day followed by 250 mg once daily on days 2-5. Genital ulcer disease (chancroid), non-gonococcal urethritis/cervicitis 1 g as single dose. Gonococcal urethritis/cervicitis 2 g as single dose. Childn ≥2 yr Pharyngitis/tonsillitis Usual dose: 12 mg/kg once daily for 5 days. Max dose: 500 mg/day, ≥6 mth Acute bacterial sinusitis 10 mg/kg once daily for 3 days. Acute otitis media Usual dose: 30 mg/kg as single dose; alternative dose: 10 mg/kg once daily for 3 days or 10 mg/kg as single dose on the 1st day followed by 5 mg/kg on days 2-5. CAP 10 mg/kg as single dose on the 1st day followed by 5 mg/kg on days 2-5.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to azithromycin or other macrolide antibiotics.
Special Precautions
Hypersensitivity. May cause liver damage. Discontinue in symptoms of malaise, nausea, vomiting abdominal colic & fever. Reappearance of allergic reaction. May mask or delay symptoms of incubating gonorrhea or syphilis; perform appropriate culture & susceptibility tests prior to initiating treatment. Prolonged use may result in fungal or bacterial superinfection, eg, C. difficile-associated diarrhea & pseudomembranous colitis. Patients at risk of prolonged cardiac repolarization; w/ myasthenia gravis; preexisting liver disease; hepatic impairment w/ or w/o jaundice. Renal dysfunction; patients w/ GFR <10 mL/min. Pregnancy & lactation.
Adverse Reactions
Diarrhea, nausea, abdominal pain, anorexia, cramping, vomiting, oral candidiasis; pruritus, rash; vaginitis, acute renal failure; arrhythmias, hypotension; aggressive reaction, anxiety, hyperactivity, paresthesia, syncope; thrombocytopenia; cholestatic jaundice; hearing disturbances (eg, deafness &/or tinnitus), taste loss & smell perversion; arthralgia, edema.
Drug Interactions
Avoid concomitant use w/ artemether, BCG, dronedarone, lumefantrine, nilotinib, pimozide, quinine, tetrabenazine, thioridazine & ziprasidone. May increase effects of cardiac glycosides, cyclosporine, dronedarone, pimozide, QTc-prolonging agents, quinine, tacrolimus, tetrabenazine, thioridazine, vit K antagonist & ziprasidone. Effect may be increased by alfuzosin, artemether, chloroquine, ciprofloxacin, conivaptan, gadobutrol, lumefantrine, nilotinib & quinine. May decrease effects of BCG & typhoid vaccine.
MIMS Class
ATC Classification
J01FA10 - azithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.
Presentation/Packing
Form
Hofmax cap 250 mg
Packing/Price
1 × 6's
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