Azithromycin is a metabolism substrate of CYP3A4 (minor) and CYP3A4 inhibitor (weak). Avoid concomitant use of azithromycin with artemether, BCG, dronedarone, lumefantrine, nilotinib, pimozide, quinine, tetrabenazine, thioridazine and ziprasidone.
Azithromycin may increase the effects of cardiac glycosides, cyclosporine, dronedarone, pimozide, QTc-prolonging agents, quinine, tacrolimus, tetrabenazine, thioridazine, vitamin K antagonist and ziprasidone.
The effect of azithromycin may be increased by alfuzosin, artemether, chloroquine, ciprofloxacin, conivaptan, gadobutrol, lumefantrine, nilotinib and quinine.
Azithromycin may decrease the effects of BCG and Typhoid vaccine.