Ovarian & small cell lung carcinoma
by IV infusion over 30 min daily for 5 consecutive days, starting on day 1 of a 21-day course. A min of 4 courses is recommended. In the event of severe neutropenia during any course, reduce dose by 0.25 mg/m2
for subsequent courses. Alternatively, G-CSF may be given following the subsequent courses (before resorting to dose reduction) starting from day 6, 24 hr after the completion of topotecan administration. Cervical cancer
Initial dose: 0.75 mg/m2
by IV infusion over 30 min daily on days 1, 2 & 3. Administer cisplatin IV infusion 50 mg/m2
on day 1 & following topotecan dose. Repeat every 21 days for 6 courses or until progressive disease.