Hypersensitivity. Liver disease; skin disease or infection at site of inj. Administer after removal of inflammation caused by deformative OA of the knee. Local relaxation is recommended after administration. Administer accurately into articular cavity. Do not administer into blood vessels or use for ophthalmological purposes. Concomitant use w/ 4th grade ammon salt eg, benzalkonium Cl, bacterial disinfectant & chlorhexidine. Pregnancy & lactation. Childn. Elderly.