Nausea, diarrhea, vomiting, staining of teeth and/or tongue. In common with virtually all other broad spectrum antibiotics, pseudomembranous colitis has been reported.
Eosinophilia, leukopenia, neutropenia, including agranulocytosis, thrombocytopenia, thrombocytosis, and decreased hemoglobin, pancytopenia and prolonged prothrombin time have been reported. A positive direct Coomb's test may develop in some individuals.
As with other beta-lactam antibiotics, CNS side effects such as myoclonic activity, psychic disturbances, including hallucination, confusional states, or seizures have been reported, paresthesia, encephalopathy.
Rash, pruritus, urticaria, erythema multiforme, Stevens-Johnson syndrome, angioedema, toxic epidermal necrolysis (rarely), exfoliative dermatitis (rarely), candidiasis, fever including drug fever, anaphylactic reactions.
Oliguria/anuria, polyuria, acute renal failure (rarely). The role of imipenem/cilastatin sodium in changes in renal function is difficult to assess, since factors predisposing to pre-renal azotemia or to impaired renal function usually have been present. Elevations in serum creatinine and blood urea nitrogen have been observed. Urine discoloration. This is harmless and should not be confused with hematuria.
Erythema, local pain and induration, phlebitis and/or thrombophlebitis.
Increases in serum transaminases, bilirubin and/or serum alkaline phosphatase; hepatic failure (rarely), hepatitis (rarely) and fulminant hepatitis (very rarely).