Individualized dosage. Infusion Prophylaxis of bleeding
Usual dose: 20-40 IU factor VIII/kg body wt administered at 2-3 days intervals. Early haemarthrosis, muscle or oral bleeding
20-40 IU factor VIII/dL. Repeat every 12-24 hr for at least 1 day until bleeding is resolved. More extensive haemarthrosis, muscle bleeding or haematoma
30-60 IU factor VIII/dL. Repeat every 12-24 hr for 3-4 days until pain & acute disability are resolved. Life-threatening haemorrhages
60-100 IU factor VIII/dL. Repeat every 8-24 hr until threat is resolved. Minor surgery including tooth extraction
30-60 IU factor VIII/dL every 24 hr, at least 1 day, until healing is achieved. Major surgery
80-100 IU factor VIII/dL (pre- & post-op). Repeat every 8-24 hr until adequate wound healing then continue for at least 7 days to maintain factor VIII at 30-60% (IU/dL).