Indocyanine green


Generic Medicine Info
Indications and Dosage
Intravenous
Assessment of cardiac output
Adult: 5 mg injected rapidly via a cardiac catheter. Max: 2 mg/kg. Doses are usually given in 1 mL volume and for an average of 5 dilution curves for each procedure. To prevent haemolysis, flush dye from catheter with normal saline.
Child: Infants 1.25 mg; Children 2.5 mg. Max: 2 mg/kg. Doses are injected rapidly via a cardiac catheter.

Intravenous
Assessment of hepatic function
Adult: Patient on fasting, basal state: 0.5 mg/kg injected rapidly into the lumen of an arm vein; do not allow the dye to escape outside the vein. If the photometric method is used, withdraw 6 mL of venous blood from the patient's arm for serum blank and standard curve construction before injection, and inject the correct amount of dye through the same needle.
Child: Same as adult dose.

Intravenous
Choroidal vasculature examination
Adult: During ophthalmic angiography: Up to 40 mg depending on the imaging equipment and technique used. Doses may be given via the antecubital vein, immediately flushed with 5 mL bolus of normal saline.
Reconstitution
Reconstitute with the supplied sterile water for inj. Instructions for reconstitution may vary between indication and doses to be given. Refer to specific product guidelines.
Contraindications
Hypersensitivity to iodides.
Special Precautions
Pregnancy and lactation.
Adverse Reactions
Significant: Rarely, allergic reactions.
Gastrointestinal disorders: Nausea, vomiting, faecal discolouration (green).
Nervous system disorders: Headache.
Skin and subcutaneous tissue disorders: Pruritus, urticaria, diaphoresis.
Potentially Fatal: Anaphylaxis (during cardiac catheterisation).
IV/Parenteral: C
Drug Interactions
May cause a decrease in absorption peak with heparin and preparations containing sodium bisulfite.
Lab Interference
May cause an increase in serum inorganic iodide concentrations and a decrease in radioactive iodide uptake; allow at least 1 week washout period before performing radioactive iodine test.
Action
Description: Indocyanine green is a water-soluble, tricarbocyanine dye that allows the recording of the indicator-dilution curves for the purpose of diagnosis and research, independent to fluctuations in oxygen saturation.
Pharmacokinetics:
Distribution: Distributed in the blood and taken up by the hepatic parenchymal cells. Plasma protein binding: 95%, mainly to albumin.
Excretion: Via bile (free form). Elimination half-life: 2.2-3 minutes.
Chemical Structure

Chemical Structure Image
Indocyanine Green

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 11967809, Cardio-Green. https://pubchem.ncbi.nlm.nih.gov/compound/11967809. Accessed Apr. 26, 2021.

Storage
Store between 20-25°C. Protect from light.
ATC Classification
V04CX01 - indocyanine green ; Belongs to the class of other diagnostic agents.
References
Anon. Indocyanine Green (Diagnostic: Cardiac). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 03/02/2021.

Anon. Indocyanine Green (Diagnostic: Hepatic). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 03/02/2021.

Anon. Indocyanine Green. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 03/02/2021.

Buckingham R (ed). Indocyanine Green. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/02/2021.

Diagnogreen Injection (Daiichi Sankyo Propharma Co., Ltd.). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 03/02/2021.

IC-Green (Akorn, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/02/2021.

Indocyanine Green. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 03/02/2021.

Disclaimer: This information is independently developed by MIMS based on Indocyanine green from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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