Generic Medicine Info
Indications and Dosage
Peripheral arteriography
Adult: Use 300 mg iodine/ml (Iopamidol inj 61%). Femoral or subclavian artery: 5-40 ml. Aorta for a distal runoff: 25-50 ml. Up to 250 ml has been used.

Selective visceral arteriography or aortography
Adult: Use 370 mg iodine/ml (Iopamidol inj 76%). Larger vessels e.g. aorta or coeliac artery: Up to 50 ml. Renal artery: Up to 10 ml. Lower doses are often sufficient. Total multiple doses up to 225 ml have been used.

Cerebral arteriography
Adult: Use 300 mg iodine/ml (Iopamidol inj 61%). Carotid puncture or transfemoral catheterisation: 8-12 ml. Total multiple doses for procedure up to 90 ml.

Coronary arteriography and ventriculography
Adult: Use 370 mg iodine/ml (Iopamidol inj 76%). Selective coronary artery: 2-10 ml. Ventriculography or nonselective opacification of multiple coronary arteries following inj at the aortic root: 25-50 ml. Total dose for combined procedures up to 200 ml has been used. EKG monitoring is essential.

Child: Use 370 mg iodine/ml (Iopamidol inj 76%). For single inj: <2 yr: 10-15 ml; 2-9 yr: 15-30 ml; 10-18 yr: 20-50 ml. Administer by inj into a large peripheral vein or by direct cardiac catheterisation. For cumulative inj: <2 yr: 40 ml; 2-4 yr: 50 ml; 5-9 yr: 100 ml; 10-18 yr: 125 ml.

Computed tomography imaging
Adult: Head: 250 mg iodine/ml (Iopamidol inj 51%): 130-240 ml; 300 mg iodine/ml (Iopamidol inj 61%): 100-200 ml. Administer by IV infusion. Body: 250 mg iodine/ml (Iopamidol inj 51%): 130-240 ml; 300 mg iodine/ml (Iopamidol inj 61%): 100-200 ml. Administer by rapid IV infusion or bolus inj. Total dose for procedure should not exceed 60 g of iodine.
Child: 250 mg iodine/ml (Iopamidol inj 51%): 1.2-3.6 ml/kg; 300 mg iodine/ml (Iopamidol inj 61%): 1-3 ml/kg. Total dose should not exceed 30 g of iodine.

Excretory urography
Adult: 250 mg iodine/ml (Iopamidol inj 51%): 50-100 ml; 300 mg iodine/ml (Iopamidol inj 61%): 50 ml; 370 mg iodine/ml (Iopamidol inj 76%): 40 ml. Administer by rapid IV inj.
Child: Children: 250 mg iodine/ml (51%): 1.2-3.6 ml/kg; 300 mg iodine/ml (61%): 1-3 ml/kg. Max dose for procedure: 30 g of iodine.

Peripheral venography
Adult: Use 200 mg iodine/ml (Iopamidol inj 41%). 25-150 ml per lower extremity. Total dose for multiple injections should not exceed 350 ml.
Do not admix with other drugs.
Not for intrathecal use.
Special Precautions
May inhibit blood coagulation. Multiple myeloma or other paraproteinaemia. Sickle-cell disease. Known or suspected phaeochromocytoma (monitor closely). Hyperthyroidism. Ensure adequate hydration. History of a previous sensitivity to a contrast medium, sensitivity to iodine, bronchial asthma, hay fever and food allergy. Monitor patients with CHF. Avoid angiography in patients with homocystinuria. Severe arterial or venous disease. Severe renal impairment, combined renal and hepatic disease or anuria, especially when large doses are used. Pregnancy and lactation.
Adverse Reactions
Arrhythmias, arterial spasm, flushing, vasodilatation, angina, cardiopulmonary arrest; dizziness, confusion, paraesthesia, visual disturbances, seizure, paralysis, coma, temporary amnesia; inj site pain, pallor, periorbital and facial oedema; coughing, sneezing, rhinitis, asthma, apnoea, laryngeal oedema, chest tightness; watery itchy eyes, lachrymation, conjunctivitis; muscle spasm, involuntary leg movement; tremors, malaise; severe retching and choking, abdominal pain; urogenital pain, haematuria.
Potentially Fatal: Severe anaphylactoid reactions.
IT/IV/Parenteral: B
Drug Interactions
May increase risk of renal toxicity in patients with known or suspected hepatic or biliary disorder given concurrent oral cholecystographic agents.
Lab Interference
May interfere with radioactive iodine uptake studies, plasma coagulation and urine tests.
Description: Iopamidol is a nonionic iodinated radiographic contrast medium. It allows visualisation of internal body structures by opacifying the path of its flow.
Distribution: Not significantly protein-bound.
Excretion: Via urine; 2 hr (elimination half-life).
Store at 20-25°C (68-77°F).
Disclaimer: This information is independently developed by MIMS based on Iopamidol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in