Prosp Pharma
Concise Prescribing Info
As monotherapy or in combination w/ other antihypertensives for HTN. Elevated serum creatinine & proteinuria (>300 mg/day) in patients w/ type 2 diabetes, & a history of HTN.
Dosage/Direction for Use
HTN Adult Initially, 150 mg once daily. Maintenance dose: 150-300 mg once daily. Max: 300 mg/day. Patients requiring further BP reduction should be titrated to 300 mg once daily. Childn ≥13 yr Initially 150 mg once daily. Usual dose: 150-300 mg/day, 6-12 yr Initially 75 mg once daily. Usual dose: 75-150 mg once daily. Nephropathy in type 2 diabetes & HTN 300 mg once daily. Vol- & salt-depleted patients (eg, patients treated vigorously w/ diuretics or on hemodialyis), elderly & renal impairment Initially 75 mg.
May be taken with or without food.
Hypersensitivity. Pregnancy & lactation. Childn <6 yr.
Special Precautions
Severe renal impairment. Symptomatic hypotension in patients who are intravascularly depleted. Avoid K-supplement during treatment. Patients w/ unilateral or bilateral renal artery stenosis; severe CHF. Concomitant use w/ hydrochlorothiazide, K or K-sparing diuretics. Discontinue if pregnancy is detected. Childn <6 yr.
Adverse Reactions
Hyperkalemia; orthostatic hypotension; fatigue, dizziness; diarrhea, dyspepsia; upper resp infection, cough; angina, angioedema, arrhythmia, cardiopulmonary arrest, conjunctivitis, depression, dyspnea, ecchymosis, edema, epistaxis, gout, heart failure, hepatitis, hypotension, jaundice, libido increased, MI, paresthesia, sexual dysfunction, stroke, transaminase increased, urticaria.
Drug Interactions
May increase levels/effects of ACE inhibitors, amifostine, antihypertensives, carvedilol, hypotensive agents, lithium, K-sparing diuretics, rituximab. Levels/effects may be increased by diazoxide, eplerenone, fluconazole, herbs (hypotensive properties), MAOIs, pentoxifylline, phosphodiesterase-5 inhibitors, K-salts, prostacyclin analogues, tolvaptan, trimethoprim. Levels/effects may be decreased by herbs (hypertensive properties), methylphenidate, NSAIDs, rifamycin derivatives, yohimbine. Avoid dong quai, ephedra, yohimbe, ginseng & garlic.
MIMS Class
Angiotensin II Antagonists
ATC Classification
C09CA04 - irbesartan ; Belongs to the class of angiotensin II receptor blockers (ARBs). Used in the treatment of cardiovascular disease.
Irbezar tab 150 mg
3 × 10's
Irbezar tab 300 mg
3 × 10's
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