Patients w/ metastatic carcinoma of the colon or rectum whose disease has recurred or progressed following 5-FU therapy. Non-small & small cell lung cancer, cervical, ovarian & esophageal cancer, malignant glioma & inoperable or recurrent gastric cancer.
Dosage/Direction for Use
Metastatic carcinoma of the colon & rectum Monotherapy: 350 mg/m2 over 90 min infusion every 3 wk. Combination w/ 5-FU, w/ or w/o folinic acid: 180 mg/m2 every 2 wk. Other indicated cancerCombination w/ cisplatin: 65 mg/m2 & cisplatin 30 mg/m2 in repeated 6-wk cycle, comprising wkly followed by a 2-wk rest.
Hypersensitivity to irinotecan, topotecan or other camptothecin analogues. Pregnancy.
Diarrhea; renal & hepatic impairment; history of bleeding disorder; carcinogenicity, mutagenicity, impairment of fertility.