Irribow

Irribow

ramosetron

Manufacturer:

Astellas Pharma

Distributor:

Zuellig Pharma

Marketer:

Daiichi Sankyo
Concise Prescribing Info
Contents
Ramosetron HCl
Indications/Uses
Diarrhea-predominant irritable bowel syndrome in males.
Dosage/Direction for Use
Adult 5 mcg once daily. Max dose: 10 mcg/day.
Administration
May be taken with or without food.
Special Precautions
Female patients. Chronic constipation or constipation-predominant irritable bowel syndrome. Rule out large intestine carcinoma, inflammatory bowel disease & enteritis infections prior to therapy. History of abdominal operation. Constipation, hard faeces, abdominal pain, bloody stool. Elderly. Childn.
Adverse Reactions
Abnormal laboratory findings; constipation & its complications; hard faeces. Shock & anaphylactoid symptoms; ischaemic colitis, abdominal distension/pain, increased liver enzymes.
Drug Interactions
Plasma conc may be increased by CYP1A2 inhibitors. Increased plasma conc w/ fluvoxamine. Intensified adverse reactions by anticholinergics, TCAs, phenothiazine derivatives, MAOIs, antidiarrheals, loperamide HCl, opium alkaloid-based narcotics, opium tincture.
ATC Classification
A03AE - Serotonin receptor antagonists ; Used in the treatment of functional bowel disorders.
Presentation/Packing
Form
Irribow FC tab 5 mcg
Packing/Price
28's
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