Isoptin SR

Isoptin SR

verapamil

Manufacturer:

Abbott

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Verapamil HCl
Indications/Uses
Essential HTN, CAD, paroxysmal supraventricular tachycardia, atrial fibrillation (AF).
Dosage/Direction for Use
Adult 120-480 mg in 1-2 divided doses.
Administration
Should be taken with food: Swallow whole, do not chew/crush.
Contraindications
CV shock, 2nd-3rd AV block, sick sinus syndrome, heart failure w/ left ventricular ejection fraction <35%, AF w/ accessory bypass tract. Concomitant use w/ ivabradine.
Special Precautions
Complicated acute MI, heart block/1st degree AV block/bradycardia/asystole, neuromuscular transmission disorders. Severe hepatic/renal impairment.
Adverse Reactions
Dizziness, headache, bradycardia, flushing, hypotension, constipation, nausea, peripheral edema.
Drug Interactions
Concomitant use w/ α-blockers (prazosin, terazosin), antiarrhythmics (flecainide, quinidine), antiasthmatics (theophylline), anticonvulsants/anti-epileptics (carbamazepine, phenytoin), antidepressants (imipramine), antidiabetics (glyburide, metformin), anti-gout (colchicine), anti-infectives (clarithromycin, erythromycin, rifampicin, telithromycin), antineoplastics (doxorubicin), barbiturates (phenobarb), benzodiazepines & other anxiolytics (buspirone, midazolam), β-blockers (metoprolol, propranolol), cardiac glycosides (digitoxin, digoxin), H2 receptor antagonists (cimetidine), immunologics/immunosuppressives (cyclosporine, everolimus, sirolimus, tacrolimus), lipid lowering agents (atorvastatin, lovastatin, simvastatin), serotonin receptor agonists (almotriptan), uricosurics (sulfinpyrazone), anticoagulants (dabigatran), direct oral anticoagulants, ivabradine, grapefruit juice, St. John's Wort.
MIMS Class
Calcium Antagonists
ATC Classification
C08DA01 - verapamil ; Belongs to the class of phenylalkylamine derivative selective calcium-channel blockers with direct cardiac effects. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Isoptin SR tab 240 mg
Packing/Price
30's
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