Itraconazole GPO

Itraconazole GPO Dosage/Direction for Use

itraconazole

Manufacturer:

GPO

Distributor:

GPO
Full Prescribing Info
Dosage/Direction for Use
Oral: Usual dosage ranges: Children: Efficacy and safety have not been established; a small number of patients 3-16 years of age have been treated with 100 mg/day for systemic fungal infections with no serious adverse effects reported. A dose of 5 mg/kg once daily was used in a pharmacokinetic study using the oral solution in patients 6 months to 12 years; duration of study was 2 weeks.
Adults: 100-400 mg/day; doses >200 mg/day are given in 2 divided doses; length of therapy varies from 1 day to >6 months depending on the condition and mycological response.
Maximum dose: 400 mg/day, but this may differ depending on indication.
Indication-specific dosing: Adults: Aspergillosis, invasive (salvage therapy): Duration of therapy should be a minimum of 6-12 weeks or throughout period of immunosuppression: Oral: 200-400 mg/day; Note: 2008 IDSA guidelines recommend 600 mg/day for 3 days, followed by 400 mg/day.
Appropriate use: Itraconazole should NOT be used for voriconazole-refractory aspergillosis since the same antifungal and/or resistance mechanism(s) may be shared by both agents. Itraconazole oral solution and capsule formulations are not bioequivalent or interchangeable. Due to variable bioavailability of oral preparations, therapeutic drug monitoring advisable.
Aspergillosis, allergic (ABPA, sinusitis): 200 mg/day; may be used in conjunction with corticosteroids.
Blastomycosis: 200 mg 3 times/day for 3 days, then 200 mg twice daily for 6-12 months; in moderately-severe to severe infection, therapy should be initiated with ~2 weeks of amphotericin B.
Brain abscess: Cerebral phaeohyphomycosis (dematiaceous): 200 mg twice daily for at least 6 months with amphotericin.
Coccidioidomycosis: 200 mg twice daily.
Histoplasmosis: 200 mg 3 times/day for 3 days, then 200 mg twice daily (or once daily in mild-moderate disease) for 6-12 weeks in mild-moderate disease or ≥12 months in progressive disseminated or chronic cavitary pulmonary histoplasmosis; in moderately-severe to severe infection, therapy should be initiated with ~2 weeks of a lipid formation of amphotericin B. Long-term suppression therapy: 200 mg/day.
Meningitis: Coccidioides: 400-800 mg/day.
Appropriate use: Fluconazole is preferred for meningeal infections.
Onychomycosis: 200 mg once daily for 12 consecutive weeks; alternative "pulse-dosing" may be considering for fingernail involvement only: 200 mg twice daily for 1 week; repeat 1-week course after 3-week off-time.
Pneumonia: Coccidioides: Mild-to-moderate: 200 mg twice daily.
Coccidioides, HIV-positive (focal pneumonia): 200 mg 3 times/day for 3 days, then 200 mg twice daily.
Protothecal infection: 200 mg once daily for 2 months.
Sporotrichosis: Lymphocutaneous: 100-200 mg/day for 3-6 months.
Osteoarticular and pulmonary: 200 mg twice daily for 1-2 years (may use amphotericin B initially for stabilization).
Dosing adjustment in renal impairment: Use with caution in patients with renal impairment. The following guidelines have been used by some clinicians: Clcr >10 mL/minute: No adjustment recommended, Clcr <10 mL/minute: Administer 50% of normal dose.
Continuous renal replacement therapy (CRRT)/hemodialysis: 200 mg every 12 hours for 4 doses, then 200 mg every 24 hours.
Hemodialysis: Not dialyzable.
Dosing adjustment in hepatic impairment: Use caution in patients with hepatic impairment.
Mode of Administration: Administer orally. Doses >200 mg/day are given in 2 divided doses; do not administer with antacids. Capsule and oral solution formulations are not bioequivalent and thus are not interchangeable. Capsule absorption is best if taken with food, therefore, it is best to administer itraconazole after meals.
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in