May enhance anticoagulant effect of coumarin anticoagulants (eg, warfarin). Increased risk of bleeding w/ factor Xa inhibitor. May enhance hypoglycemic effect of sulfonylurea hypoglycemic agents (eg, tolbutamide). May enhance convulsant effect of new quinolone antimicrobial agents (eg, levofloxacin hydrate). May increase plasma conc of methotrexate & lithium. May reduce diuretic-antihypertensive effects of thiazide diuretics (eg, hydrochlorothiazide). May reduce antihypertensive effects of antihypertensive drugs (eg, ACE inhibitors, angiotensin II receptor antagonists).