Jovia 20

Jovia 20

escitalopram

Manufacturer:

Great Eastern Drug

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Escitalopram oxalate
Indications/Uses
Acute & maintenance treatment of major depressive disorder in adults & adolescents 12-17 yr. Acute treatment of generalized anxiety disorder in adults. Panic disorder w/ or w/o agoraphobia. Social anxiety disorder. Obsessive-compulsive disorder.
Dosage/Direction for Use
Adult Major depressive episodes Usual dose: 10 mg once daily. May be increased to a max of 20 mg daily after a min of 1 wk. Generalized anxiety disorder Initially 10 mg once daily. Dose may be increased to 20 mg daily after a min of 1 wk. Panic disorder w/ or w/o agoraphobia Initially 5 mg for the 1st wk before increasing the dose to 10 mg daily. Dose may be increased up to a max of 20 mg daily depending on individual patient response. Social anxiety disorder Usual dose: 10 mg once daily. Depending on individual patient response, dose may be decreased to 5 mg or increased to a max of 20 mg daily. Obsessive-compulsive disorder Initially 10 mg once daily. Depending on individual response, dose may be increased to a max of 20 mg daily. Childn & adolescents (12-17 yr) Major depressive episodes Initially, 10 mg once daily. May be increased to a max of 20 mg daily after a min of 3 wk. Elderly (>65 yr) Initially 5 mg once daily. Dose may be increased to 10 mg daily. Patients w/ mild or moderate hepatic impairment &/or poor CYP2C19 metabolisers Initially 5 mg daily for the first 2 wk. Dose may be increased to 10 mg daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to escitalopram & citalopram. Concurrent or recent use (ie, w/in 2 wk) w/ a MAOIs. Concomitant use w/ pimozide.
Special Precautions
Increased risk of suicidal thinking & behavior in childn, adolescents & young adults w/ major depressive disorder & other psychiatric disorders. Monitor & closely observe for clinical worsening, suicidality & unusual changes in behavior during initiation of therapy & during periods of dosage adjustments. Previous seizure disorder or conditions predisposing to seizures eg, brain damage, alcoholism, or concurrent use w/ drugs that lower seizure threshold. May cause hyponatremia, vol depletion. Elderly; patients w/ a history of falls or fractures & may cause or exacerbate syndrome of inappropriate antidiuretic hormone secretion or hyponatremia. Monitor Na closely w/ initiation or dosage adjustments in older adults. History of mania. May increase the risk of bleeding. Concurrent use of aspirin, NSAIDs, warfarin & other anticoagulants. May increase the risks associated w/ electroconvulsive therapy. Potentially life-threatening serotonin syndrome in concomitant use w/ other serotonergics (eg, triptans, TCAs, fentanyl, lithium, tramadol, buspirone, St. John's wort, tryptophan) or agents that impair metabolism of serotonin (eg, MAOIs); discontinue use if signs & symptoms occurs. Females w/ preexisting QT prolongation or other risk factors (eg, hypokalemia, other cardiac disease). Severe renal or hepatic impairment; concomitant use w/ CNS depressants. May cause mild papillary dilation which may lead to narrow-angle glaucoma. Evaluate patients who have not had an iridectomy for narrow-angle glaucoma risk factors. Pregnancy & lactation.
Adverse Reactions
Abnormal dreams, anorgasmia, dizziness, drowsiness, fatigue, headache, insomnia, lethargy, paresthesia, yawning; diaphoresis; decreased libido, menstrual disease; abdominal pain, constipation, decreased appetite, diarrhea, dyspepsia, flatulence, nausea, toothache, vomiting, xerostomia; ejaculatory disorder, impotence, UTI (childn); back pain (childn), neck pain, shoulder pain; flu-like symptoms, nasal congestion (childn), rhinitis, sinusitis.
Drug Interactions
Increased peak plasma conc & AUC of CYP2D6 isoenzyme substrates (eg, desipramine, metoprolol), & cimetidine. Increased bleeding w/ warfarin or other anticoagulants. Serotonin syndrome or NMS-like reactions w/ antipsychotic agents or other dopamine antagonists, 5-HT1 receptor agonists (eg, almotriptan, eletriptain, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan), MAOIs (eg, INH, linezolid), citalopram, sibutramine. Alcohol, CNS-active drug, lithium.
MIMS Class
Antidepressants
ATC Classification
N06AB10 - escitalopram ; Belongs to the class of selective serotonin reuptake inhibitors. Used in the management of depression.
Presentation/Packing
Form
Jovia 20 FC tab 20 mg
Packing/Price
2 × 14's
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