Avoid using or using with careful dosage in patients with or having close-relatives with hearing impairment caused by Streptomycin or any other hearing impairment.
Administer carefully to the following patients:
Patients with renal impairment.
Orally poorly nourished or parenterally nourished patients, elderly patients and patients in poor general health. (Sufficient observation should be performed because vitamin K deficiency may develop.)