Kary Uni

Kary Uni

pirenoxine sodium




Full Prescribing Info
Each mL contains pirenoxine 0.05 mg.
It also contains the following excipients: Disodium edetate hydrate, benzalkonium chloride, concentrated glycerin and polysorbate 80.
Kary Uni is an orange, sterile aqueous suspension. Chemically, pirenoxine is known as 1-hydroxy-5-oxo-5H-pyrido-(3,2,a)-phenoxazine-3-carboxylic acid. It has a pH of 3.4-4 and an osmotic pressure ratio of 0.9-1.2.
Immediately after topical application, the pH of Kary Uni becomes equivalent to that of the lacrimal fluid, the suspended pirenoxine particles being dissolved rapidly in the lacrimal fluid.
There are various theories for the development of senile cataract but the mechanism has not been elucidated. Ophthalmic preparations of pirenoxine were developed based on the quinoid theory proposed by Ogino in 1957 and is recognized to be clinically effective for the treatment of cataract.
For incipient senile cataract.
Dosage/Direction for Use
Shake well before use.
Instill 1-2 drops 3-5 times daily.
Special Precautions
For ophthalmic use only.
Kary Uni is discolored after contamination with metal ions.
Adverse Reactions
Treatment should be discontinued if the following adverse reactions occur: Symptoms of hypersensitivity, blepharitis, contact dermatitis, diffuse superficial keratitis, conjunctival injection, irritation and itching.
Store below 30°C.
Special Instructions for Storage: Since particles in the suspension may not disperse depending on storage conditions even after shaking well, Kary Uni should be stored with the top upward.
ATC Classification
S01XA - Other ophthalmologicals ; Used in ophthalmic preparations.
Ophth susp 0.005% x 5 mL x 10's.
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