Not for monotherapy use. Moderate to severe renal impairment. May cause high rate or urological failure & emergence of resistance at an early stage w/ tenofovir disoproxil fumarate & abacavir or didanosine. Opportunistic infections & other HIV complications. Pancreatitis, lactic acidosis, mitochondrial dysfunction, lipodystrophy, immune reactivation syndrome. Chronic hepatitis B or C, hepatomegaly or other known risk factors for liver disease & hepatic steatosis. Periodic monitoring of liver function test & markers of HBV replication. Childn <3 mth. Pregnancy, lactation.