Pharmacology: Pharmacodynamics: Following actions of lysozyme have been reported: Antiviral action, antibacterial action.
Enzymatic Activity: Since the substrates of lysozyme are mucopolysaccharides, the enzyme is a kind of mucopolysaccharides and has the beta-glucosaminidase activity. The action site of lysozyme is the beta-(1-4) linkage between N-acetylmuramic acid and N-acetylglucosamine, and recent success of X-ray analysis has revealed that the active site of lysozyme is the imidazole nucleus contained in the histidine residue and that a partial active site resides in the indole nucleus in tryptophan.
Difficulty of Expectoration: LEFTOSE decomposes and dissolves mucous pus to make its discharging easy, suppresses excessive secretion of mucus, and thereby accelerates curing of the focus.
Toxicology: Toxicity: The toxicity of lysozyme chloride is so weak that LD 50 in rat is 3,550 mg/kg by intravenous administration, 5,500 mg/kg by intraperitoneal administration, and more than 20,000 mg/kg (not calculable) by oral administration. No anomalies have been observed in histological investigation after a long period of administration.